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The 12th Annual Fall Oncology Conference: Clinical Challenges in Cancer Medicine Held in Conjunction with the Ninth Annual Medical Oncology Fellows Forum has been designed to address clinical challenges and practical issues faced each day by community oncologists, registered nurses practicing in oncology, oncology physician assistants, and other oncology professionals. The conference is intended to inform oncology professionals and fellows in training of the recent data with agents approved for and being evaluated in the most common tumor types, including breast, lung, genitourinary, gastrointestinal, gynecologic and hematologic malignancies, melanoma, and glioma. Efforts will be focused on providing a thorough understanding of the toxicity profiles of controversial and evolving regimens with hormonal therapy, chemotherapy, and novel targeted agents in these cancers in order to aid oncology professionals in making effective decisions regarding treatment, patient management, and trial enrollment. Featured keynote lectures will cover current concepts in developmental therapeutics, from target discovery and validation to drug development. A portion of the conference will be devoted to providing continuing education specifically to fellows in training in order to facilitate and improve their efforts in providing patients with state-of-the-art care. Practical topics focusing on career choices in oncology, design and interpretation of clinical trials, and techniques to optimize patient care in oncology will also be introduced. Ample time will be provided for interaction between the faculty and the participants in order to allow the sharing of both clinical issues and potential solutions.