GoingToMeet

Topics covered:
• The quantitative concepts underlying cell signaling and gene regulation.
• How molecular circuits comprising genes, proteins, and their interactions give rise to different dose response behaviors.
• The shapes of dose response curves in feedback/feedforward-mediated cellular homeostatic systems.
• The molecular engine driving the cell cycle and checkpoint control, and its implications for modeling dose responses with respect to cell proliferation.
• How binary (either/or) decisions are made and how cells remember the results of these decisions.
• The noisy (stochastic) nature of gene expression and its implications for the shapes of dose response curves.
• Approaches to modeling signal transduction and gene regulatory networks.
• To use programs such as Berkeley Madonna for computational modeling of cellular response to perturbations.